Born in Carpi (modern-day province of Modena) in ca. 1468/70, Ugo da Carpi was the first Italian chiaroscuro woodcut designer. Active in Venice from around 1509, he produced several woodcuts from small book illustrations to monumental multi-block prints. Concerned with issues relating to authenticity, Ugo usually signed his works, an uncommon practice at that time. In 1516, he petitioned the Venetian Senate for the privilege of having invented the technique of chiaroscuro woodcut. however, it is likely that Ugo developed his method upon seeing earlier German examples. In his prints, Ugo abandoned the traditional cross-hatching manner in favor of the use of tone blocks. In 1516-18, Ugo moved to Rome and executed the majority of his chiaroscuro woodcuts after designs by Raphael and through the intermediary of engravings by Marcantonio Raimondi and Agostino Veneziano. After the sack of Rome in 1527, Ugo settled in Bologna where he collaborated with Parmigianino, before dying in 1532.

Raffaello Sanzio (Urbino, April 6, 1483-Rome, April 6, 1520), commonly known as Raphael, was one of the most admired Italian painters and architects on the High Renaissance. He was trained in his native city Urbino, a center of art and culture during the rule of the Duke Federico da Montefeltro. Around 1495, Raphael moved to Perugia and joined the master Pietro Perugino's workshop. He later sojourned to Siena, and then resided in Florence by the autumn of 1504. There, Raphael studied the works by Renaissance masters such as Leonardo da Vinci, Michelangelo, Fra Bartolomeo, and Masaccio. Raphael is best known for his paintings of Madonnas (from 1504 through 1507), and the frescoes that Pope Julio II commissioned to him in the Vatican Palace in Rome in 1514. The same year architect Donato Bramante died, and the pope appointed Raphael chief architect. Raphael's style was based on clarity of forms and harmonious compositions; after his death, his works were highly admired by both Mannerist and Baroque artists.